I would with any motherboard upgrade. Make sure you've got a retail licence of Windows, however.
If you dont, the drivers will go all weird, happened to me once, fresh install ANYTIME you install hardware
http://forums.overclockers.co.uk/showthread.php?t=18140510
Made a new post on the kind of same subject, didnt want to mix them. Basicly i have been offered the same brand of mb, apart from its a higher end model. Should i still reinstall windows if i do get it?