Seemed like a reasonable question to me. I have gone from a crt 17" 1280x1024 to a 22.2" (1680x1050), and then to a 26" (1920x1200). I haven't noticed that much more work for my eyes to do, but I can see where the problem might arise for one over another re : refresh rate, screen size, particularly from small to quite large over a short period of time. Rather than graduate to a 30" screen next time, I'll probably head for a 24" - 27" 120hz, or something similar.