Downsides to water cooling?

Cost. Only downside.

+1, some of the fitting's are very really costly, l just use generic one's had no problems at all and next build will buy one good radiator external use instead of two as it usually works out cheaper. Which you can carry onto your next build + fitting's keeping the cost down if you want.

I serviced my custom loop after two years[ new [tubing+pre-mix] after being on at least 14 hour's a day everyday, just used a pre-mix and just topped it up after upgrading the GPU.

The pre-mix was still clear no floaters, no change in temp's, copper CPU block discoloured slightly, see no reason not to do so again.
 
The big problem too is warranty a lot of companies don't allow for you to remove the coolers and keep your warranty for your gpu and motherboard.
 
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