Tighter timings on C2D systems show no or very very little performance gain.
PC 5400 RAM is designed for a 333 fsb CPU and Mobo.
If you ran your Mobo FSB at 333 with the E2180 using its 10 Multi then the CPU would be running at 3330 Ghz (333x10) which is the stock speed of PC5400 Ram.
If you instaled PC6400 Ram then it would be running at well below its stock speed (333 rather than 400). Now you could just crank up the fsb to 400 but this would need a lot of CPU VCore and top notch cooling.
I only used PC5400 Ram cos it was a fair bit cheaper than PC5400 stuff and as anything over 3.3ghz would probably have needed better cooling.
Now if you get PC6400 ram (400fsb) you could drop the multiplyer and raise the FSB for the same CPU speed but with more bandwidth due to the higher FSB.
1 320fsb x 10 multi = 3.2ghz
2 400fsb x 8 multi = 3.2ghz
Option 2 would run faster due to the higher bandwidth, although this is more pronounced in quad cores as they are bandwidth hungry beasts.
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Yeah, Core 2 Duo systems don't seem to benefit from low latency's as much as the old AMD chips used to.
Id still have to say getting PC6400 would be the right way to go, add to the fact pretty much any modern c2d board will happily run at 450mhz with dual cores you can safely say the cpu's cooling solution will be the limiting factor.
An E2140 has the ideal multiplier for this setup and I think its the idal cpu to go for in this case. I just dont see the point spending more on the E2180 only to drop the multi.