grrr, i just accidentally killed a villager or 7.
Doing the Toby mission and trying to scare him away but didn't do jack so i turned off safety and killed him, except i press the X button twice and the second swing killed someone standing at the door, then a bunch of people who saw it start waving guns and since their glow was red and shooting me so I killed them.
Now i am called a murderer everywhere despite being 99% pure and Good still.
I had a similar problem, after I did a couple quests they calmed down.
I'm having problems with my son on the rescue quest - I've saved him from the hobbes and climbed out of the cave but every time I try to go anywhere on the map I'm warned that my progress will be lost and I'll have to restart the quest. My son has disappeared too.

Does she get angry if you try to "cheat" on her?