I briefly remember somebody here a few months ago being refused a job because he said he doesn't use social media. They basically called him a liar for it and never got the job.
I could see it being a negative if you're going for something in say marketing, online advertising etc.. etc..
In some of those fields it could be like applying for an IT job with a paper CV containing just your address and phone number because, well, you don't use e-mail.