Good free registry cleaner?

Have never seen a registry cleaner do anything noticebly good to a system, have seen them cause lots of noticable damage though...
 
What kind of damage? This is making me think twice about ever running one again.

Destroyed add/remove programs list and general un/installation issues.
Messed up firewall/security centre.
Messed up file associations.

Off the top of my head.
 
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