Help!! iMac Won’t Boot!

You have four USB3 ports and two Thunderbolt 1 ports. Performance via either of those won't be an issue.

It's worth mentioning, the majority* of USB enclosures don't offer TRIM support which could impact performance hence a Thunderbolt enclosure is the better solution albeit more costly.

* Supposedly a few USB bridges do offer TRIM support but i've yet to read of a USB enclosure where TRIM is fully supported under MacOS - typically it's confirmed under Windows/Linux.
 
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