About 60% or so, sometime around X'mas year, on my friend's old AMD 3800 system with a single 160GB Hitachi SATA drive that was under heavy workload. The filesystem was all messed up since it was not defragged for nearly a year, and the drive was also running low on space (approx 10% free), so plenty of fragmentation as well an MFT in multiple pieces.
Ran a disk cleanup to make some room and trash the junk files, then installed Diskeeper 2k9 pro trial version, and ran it in autodefrag mode for a couple of hours followed by a boot-time defrag. It gave a new lease of life to the system, and performance was back up to normal Since then, he's put in another HDD too so the storage load is a bit more balanced now; also he began defragging more regularly, and the system runs okay.