As mike said higher multi - less stress pc - lower volts - less heat.
Running at a higher multi may allow you to undervolts the cpu and NB (droping temps further)
Higher multi cpu's allow for the use of slower ram or fast ram at tighter timings/reduced speed
But 180x20 is slower that 200x18. (run superPi and see for yourself)
as FSB affect cpu, NB, Ram etc.