Doesn't seem to be a whole lot of logic and common sense in this thread!
It's all either,
- OMG PSUs are so dangerous! Never even look at one if you arnt an electrical engineer!111!!!!
or
- LOL Im a crazy suicidal nutter who opens all my PSU s up while they're plugged into 240V and running! Oh and BTW I have a death wish!
You don't need to be an engineer to build PCs and you dont need to be an engineer to mod a PSU, providing you have a bit of basic knowledge and are careful.
PSUs store charge in big capacitors. If you know what these are and what they look like then just don't touch them! If you dont know what these look like, then prolly better off not bothering.
It is true that these capacitors can store a heck of a kick and its takes a while for them to discharge properly. However, if you switch the computer off at the mains and then press the power button of the PC, a good bit of the charge will be drained instantly.
Ive opened up PSUs a couple of times to clean dust out of them properly and while I've not actually changed a fan, it's not going to be rocket science, as said above.
Of course, having said all that, PSUs can still potentially be very dangerous and often times a new, quieter PSU would be a better bet rather than changing a fan. In general tho, you should be fine so long as you don't touch, or drop a screwdriver, across the terminals of a big fat capacitor!
But messing about with a PSU while it is switched on is frankly madness. You do need to have a bit of respect for the things.