I played through Mass Effect 6 or 7 times for the many outcomes and endings, playing as good characters and bad characters etc, it's my all time favourite game/trilogy. Without a shadow of a doubt, full Biotic was easily my most enjoyable, and playing at the hardest difficulty as well. Starting out will be rough, but the reward and fun you have as you see your powers improve is massively satisfying. You can really control the battlefield with them, do not be frightened of only using pistol as your powers are way more superior. Playing as a Biotic makes the combat way more tactical and enjoyable in my opinion.