Most over powered thing in a video game??

Full 100% invisibility suit in Elder Scrolls Oblivion once you have access to the arcane university and a high enough level casting.

No enemies can see you or will retaliate when you attack them.
 
Most recent example I can think of is a couple of the plasmids from Bioshock 2. Using decoy along with hypnotize seemed to ease the difficulty way beyond the normal level of weapon balance you would usually find in a game.
 
Street Fighter IV - Sagat

Super Street Fighter II Turbo - Akuma

World of Warcraft: Wrath of the Lich King - Death Knights shortly after release and again later on during Ulduar days with Frost builds + Ulduar sigil
 
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