Mouse question

[fantasticCG]

Hi been playing bioshock with the controller its very smooth.
When using the mouse the input lag is bad! very jittery,
I have turned off windows mouse acceleration and the in game acceleration.
I'm using the m65 mouse and have lowered the dpi setting to 400.
Any other ideas or thoughts

 

[fantasticCG]

Thanks guys ill give it a whirl, there's a touch of it in most games.
That I put down to sli, which seems fine when I use an Xbox controller in all the single player games. Online I use M+K