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Nothing happens at all, I'll change the number, hit apply and then it just goes back to 0.
I'm currently using the MSI 290 GE.
Strangely enough MSI Gaming Editions seem to have the most problems with MSI Afterburner.
If you have the MSI Gaming App installed get rid of it but switch back to performance mode first.
It's just a very simple OCing tool for beginners. It allows you to put the card into 2 "modes"; gaming, eco and there's also a button to revert factory settings.
http://www.guru3d.com/files_details/msi_gaming_app_download.html
I suspect they do something funky with the BIOS of these cards (to allow for the "modes") which causes problems with AB.