There wont be a 'big bang' breakthrough when it comes to nano technology - it will simply be a continuation of what we're already seeing.
Lets face it, look at cpu fabrication - we've gone from130nm processes to 90nm process, and i think i read soemwhere that IBM are looking into a 30nm process.
Sooner or later things like CPUs will have portions built with 'bottom-up' nano-technology, rather than 'top down' lithography, but at the end of the day there wont be a big change, as the 'top end' of nano is close to the 'bottom end' of conventional technology....