Yes, because its extremely unlikely their localised effects have any bearing on our galaxy/solar system and can be ignored. For example their planets would be largely irrelevant to us and could be represented by single objects of mass if needed, rather than the entire life and death of the planet itself.Well that's still pretty dubious - you're now talking about approximations, that might well be great for physics simulations but you're then introducing errors and excluding any outside event beyond that localised simulation especially if this is getting down to simulating individual humans and how they end up behaving etc..
Some of these humans are going to look at the stars - some subset of human relationships, babies born, engagements made, first dates etc.. might happen under said stars... now your closed simulation doesn't have them...
Oh but you'll perhaps now have to wiggle back a bit - will you approximate those stars?
A rough calculation to work out when the star change into a state that has effects on us other than light e.g. pulsar that could have us in it's polar line of sight and then that is simulated in finer detail for those events, and the "butterfly effect" that's had on our solar system is calculated.
This way you can remove vast amount of unnecessary calculation.
There is no other way. I cannot convince you that 100% accurate simulation of an entire multiverse is possible, and you can neither convince the opposite. What I can say is that due to our limited knowledge of phenomena outside of our current scientific knowledge e.g. dark matter, string theory (if they still have that on the table), is that whatever is on the layer below quantum effects may make simulating them quickly, more feasible due to compression calculations or shortcuts that give us the same results.The answer to these objections so far is basically a hand waving one of magical things being possible because future technology....
Not everything is equally weighted by quantum change. Sure in Schroedingers cat its the driving force and heavily weighs on the outcome of that scenario. But for a rocky moon with very few isotopes and shielded from radiation by the sun or moon there is much less random deviation over a longer period of time that needs to be calculated - so you can cut chunks of solving out of it because its not needed. For objects that are not static over much shorter durations, it is needed. The butterfly effect that occurs between those two extremes can be iterated such that it can be ruled out in N simulations in that localised area.
However, I do believe there is a non-zero chance that in the future we can simulate everything entirely without shortcuts. I do not need to believe it to appreciate the probability of the idea. And so by definition I believe Roko's Basilik is also possible, just less possible if we are only living in one universe. If it's the multiverse, then the chance that any conceivable action can happen has a much higher probability