Jebus is a name for Jesus used by Homer Simpson on the television program The Simpsons. It is also mentioned by a Catholic Cardinal on an episode of Family Guy.
According to Matt Groening, The Simpsons writers have an ongoing competition to write a line that "most represents Homer at his singularly most stupid." Most likely the current champion is Homer's faux term for Jesus, first mentioned in the episode "Missionary: Impossible". When asked to be a missionary, Homer replies that he "[doesn't] even believe in Jebus!". When the plane that is carrying Homer is taking off, he cries, "Save me Jebus!"
There are several theories of earlier uses of this misspelling. One attributes it to Frank Zappa, of whom Matt Groening is a fan. The earliest says it was used by jazz performer Duke Ellington, in a throwback to his Catholic school days. He used it instead of Jesus so that the nuns couldn't beat him. He used it instead of Jesus for the rest of his life, which is how Zappa probably found it.
In another animated show, Family Guy, Jebus appears as a typo on page 375 in The Bible.