Probably fine for most RPGs, especially Diablo-esq ones with a few more key bind slots, and MMO's if you're not playing a healer or support character. Obviously designed for MOBAs, but may well be nice compromise mouse for all gamers rather than the vanilla Naga which is only really suitable for non-twitch combat MMO's.
Only issues may be the price, but that's not OCUK's fault given Razer's premium pricing policy.