I also have the 500DX and came across this thread and
@doyll 's posts (thank you for the information).
I tried to follow your advice and this is my summary of what I've done so far.
I have 4 types of fan available to me:
3x Pure Wings 2 that came with my case
1x Noctua NF S12B that I've had since 2009
1x Noctua NF P12 that came with my CPU cooler (also owned since 2009)
1x Akasa Apache 120mm (AK-FN-057) (also owned since 2009)
Since the Akasa has the highest pressure rating at 2.64mm H2O I left it on my Noctua NH-U12P SE1366 as a push fan.
Then looking at the other fans, I put the 2 highest pressure rated ones as intakes which were the Noctua NF S12B (1.31mm H2O) and NF P12 (1.68mm H2O).
I took off the top mounted fans (although one Pure Wing is still there just disconnected).
I left the rear fan as an exhaust fan.
The original configuration was as follow: 1 Pure Wing rear exhaust, 1 Pure Wing + 1 Noctua NF S12B as top exhausts and 1 Pure Wing + 1 Noctua NF P12 as front intakes.
I ran Cinebench R20 and 3D Mark Timespy and monitored CPU temps for both and GPU only during timespy (peaks reported).
Cinebench: Temps went from 79.0°C to 73.8°C so a drop of around 5°C.
3D Mark: For the CPU temps went from 75.8°C down to 68.0°C so a drop of around 8°C. For the GPU temps raised from 76°C to 85°C.
Conclusion: CPU temperatures dropped whilst GPU temperatures raised.
Next steps: I will connect the 1 Pure Wing fan that I did not remove completely back as an exhaust and monitor again. I realise these fans are not the greatest, but with current shortages not much I can do. I will be purchasing some fans in future either the Phantecs that were recommended or some Arctic P14, which also seem to be held in high regard.