Because E and F aren't contiguous I can't delete E and then expand F using the unallocated space from E (in disk management). All my programs are on F and I guess if I just copy everything from F to E, then nothing will work as all the registry/shortcuts/paths are pointing to the wrong place.
C, E, F, are on a 2x250GB drive RAID0.
I, E, are on a 1TB drive.
H is on its own.