Your not going to notice anything I imagine as PhysX doesn't use much of the core at all.
Actually during borderlands 2 playthrough some area my dedicated GTX 260 physX Card would spike through 60% usage only doing physX calculations..
On another note i think nvidia is trying to push some changes to how heavy the physX is implemented in some games. They want sales which is logically which is why we see in games like borderlands 2, Batman arkham city that a dusty old 8800/200 series Card wont be enough anymore. It could be driver manipulation on purpose to slow down performance or just the sheer number of calculations gone thrugh the roof. Neither would really surprise me. I've never had anything against nvidia ( i use to run 2 gtx 560 ti and love them dearly) but their physX business has always been shady *looks at an PPU Card from ageia and crys*
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