Potential motherboard issue, Kernel Power 41

Sounds like it’s the motherboard. Try with a minimal system config. 1 stick of RAM in the first slot, pull unneeded USB, networking etc.

I have to agree with jigger at this point, you've tried:

- Turning most things off/on, XMP, C-States, PBO, etc
- Two different sets of memory
- Two different CPUs
- Two different PSUs
- fresh Windows install

I picked up a new B550 board, and so far it seems stable with the 5600. Haven't changed any default BIOS settings yet [XMP, PBO, etc] but it seems stable so far. Have installed chipset drivers, some windows updates [not all, on w10].

When I'm home later I'll turn on XMP, do the windows updates, but may stay on w10 for now. I'll let you guys know! Seems like it was a MB issue
 
Have you updated the motherboard bios to the latest version? Aside from the fact that the 5600 will need a newer bios version than the 3100 there are updates to the Agesa all of the time along with cpu performance improvements and compatibility fixes.
Yes, I did. Tried 3-4 different BIOS versions.

All were newer versions that support the 5000 series.
 
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I would do all the drivers and updates first
You need those regardless
PBO and XMP you want them
But don't need them
It should run with them enabled
But technically they're overclocking
So never 100% guaranteed to work
 
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