Definitely the Uncharted series, while it isn't an RPG it's basically a must-play for anyone who likes great games. I know many people will suggest you play the first Uncharted in order to better appreciate the characters in the second but it isn't essential, and the first does look a little dated now which might put you off, but the second and third still look utterly amazing and are still enjoyable without having the first game under your belt.
Apart from that I'd recommend MGS4, it's one of the best games I've ever played and the cutscenes are better directed and voiced than the majority of movies that are released these days, not to mention the gorgeous graphics. It's hard to suggest exclusive RPG games because the best ones are multiplatform.