To actually answer your question...it depends (see below)
Don't want to teach you to suck eggs but for the sake of those who've posted incorrect statements above: Put them in RAID0 will give you double the space and a performance boost (the writes and reads are split over both drives simultaneously so in theory should both be twice as fast). But if one fails you'll loose everything.
As to whether you just configure them from the BIOS, well sometimes that'll work and sometimes it wont. It depends on the OS and the motherboard as to whether it will boot without having to add different drivers.
My old Nvidia based board didn't seem to care what arrangements you had regarding single drives and drives in raid, you set it in the bios and it would boot, even migrating installs from single drives to RAID It just worked.
However my newer X58 board has different drivers for the chipset depending on how you configure the storage controller in the BIOS (IDE/ACHI/RAID). You can't move an install from one to another without installing different drivers beforehand, or better yet doing a clean install.