RAID is for high availability, it is not the same as having backups. RAID 10 will be two drives as RAID 0 (high speed, you will lose all data if one drive drops out or fails). The second two drives will be in the same format, but they will be a copy of the first two, so if one disk out of a pair fails, you still have the other pair. RAID 0 is for speed, and is not recommended if you want your data safe, which is why RAID 10 compensates by having a second pair of disks mirroring the first pair.
However, if your computer gets hit by lightning, or gets burgled, or your house burns, or you get hit by malware that encrypts your files, or if you accidentally delete your disk, all the RAID in the world won't help you. You need some kind of (preferably offline) regular backup if you absolutely cannot loose the data.
If your motherboard has the onboard RAID firmware from the Intel chipsets, it's easy to set up. The Intel RST software guides you through it, you just have to be careful to copy the right disk to your new drives.
You may find that your system gets slower, as it will have to send more data across the busses to keep all these drives updated, especially when writing. If you don't have a recent motherboard, you might notice this extra load on the system.
You're probably better off just using a couple of drives for RAID 1, and using the others in an external caddy, and setting RST to use it as a recovery drive that updates itself every ten or twenty minutes - kind of like constant backups.