There are a few variable for this, but I was talking to a guy who used the g12 with an x52 on his 2080ti - he also put copper heatsinks onto the memory, vrm and mosfets, he did find the temps dropped compared to the stock cooler, but he found he could not overclock the memory the card would crash right away.
He then decided to throw that away and get a block and put the card on a loop, the card then overclocked another 100mhz higher than the g12 + x52 AND he now found he could push +800mhz on the memory where as before +100mhz would make it crash
I don't know if perhaps his installation of the AIO wasn't good, but at least in his experience it appears the G12 + x52 resulted in a core not overclocking as well as it could and potentially memory modules overheating as well - you'll notice that in the AIO 2080ti cards, like the kingpin I recently saw a teardown of, they have a metal brace that makes contact between the memory and AIO block so that the core and memory both get direct contact. But doing your own AIO means the memory is exposed and best you can do is attach a small heatsink to it