Yes, you can have it do whatever you want pretty much.
All I've done it tell it in one of the config files, forget which, to fire up the ghost.exe process with a command line that goes straight into imaging, using an image I've included on the disc.
So you do that, make your WinPE image, then make the iso of the image, and that's it.
We use it for exactly the same purpose, have a business area we support that's not part of our main business, it's a bit of an offshoot. Seperate network and sites/servers, so they aren't hooked up to any of our ghost servers and needed an easy way to rebuild the machines.
With this method they pop the disc in and boot up and it reimages the machine. The only prompt they get is during the sysprep bootup stage where I've got it prompting for a machine name so that they all get unique standardised ones rather than the random generated ones.