Server 2003 - 100% CPU usage problem

[Dr Zoidberg]

A server running server 2003 has been experiencing problems all morning.
The CPU usage is hitting 100% most of the time but it is not a particular program/process hogging it all.
The server is not the fastest of machines we have but it normally plods along happy enough.
No updates have been installed over the weekend, and the virus scanner has not reported any thing.
killing random processes can get the cpu to spike up and down rather than stay constant at 100%.
It has been pulled from the network while we try to sort the problem, one we get the CPU graph spiking and then plug the network back in the CPU will again spike at 100% and stay there.

Any one have any ideas of what to look at or what might cause this?

I will not list everything we have tried as to be honest i can not remember everything off the top of my head,

But any ideas would be gratefully received.

 

[bledd]

task manager screenshot

 

[Burnsy2023]

task manager screenshot

I'd prefer a process explorer screenshot

http://technet.microsoft.com/en-us/sysinternals/bb896653.aspx

 

[bledd]

yes boss, a little more help in the OP is good too

 

[Dr Zoidberg]

Drastically trying to copy data from it for the last couple hours (yes there are backups but still some stuff we want to get off of it)
Will try and get a process explorer screen shot, although nothing in particular is hogging the CPU
Booting into safe mode it works fine, task manager shows the CPU graph hardly moving off the bottom of the graph and everything runs smooth, reboot and log in normal and back to 100% use again.
Disabled all services in msconfig and that did not make any difference.