I had a similar issue,(of the top of my head) if you right-click the program go on to properties>advanced tab then change it to run on Service Pack 2, this was how I fixed it.
Found another site (Skype forum) that said uninstall it, download a previous version (4.2.0.187) and install that PLUS remove autoupdate feature! Have done so and it installs / runs.
Mel
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