I know that SSD supposed to be fast and that multiple writings can destroy the drive so turning off prefetch and not defraging, but what about Swap drive.
There are programs that have problems when there are no swap. Are people using a HD as a swap?
More of an issue would be with the drive's general performance. If it's an older SSD with the buggy JMicron controller, and having to do lots of small writes to the pagefile, the performance of the drive will plummet. But really I think there's little point in disabling prefetch (defragging is, of course, totally pointless on SSD).
Basically most mainstream SSDs (OCZ et al) have a ridiculous amount of write cycles (i.e. 1.5 million) which will last for well over 10 years (one figure I read, might have been a 120GB Apex) was that if you wrote 50GB to it every day, it would take 11 years to render the drive unwriteable. Note unwriteable - I've heard even once you reach that limit, you can still read the drive and therefore recover data, it just becomes read-only. And seriously, does anyone write that much data every day?
Besides, who keeps a drive around for 10+ years?
Sure, moving your swap file off the SSD might help performance, if you have an older SSD. But if you've got a newer one, keep it on - the speed of the drive will enhance swap file performance, and (check to see how many write cycles your SSD is rated for) don't use longevity as a reason not to put the pagefile on the SSD. That was only really a problem for the first generations.