I use PRIME purely for heat testing. Seeing if you have a decent paste application/whatever.
Then normally run a bit of furmark, then some 3d mark. if anything weird such as extreme temps, over-volts show up then I notch clocks down a buit and try again.
But I have seen my PC pass 6 hours of prime, then immediately fail when loading a game.
These artificial testers are great for testing temps and volts are all with spec, but really not for stability. For this I always spend a few hours in a game with things like CPU-z, EVGA Precision X and M.O.D open to see all my temps/volts. Aslong as these are still OK after a short period of time I just keep playing.