Important to remember they have the whole 'Apple University' thing which drills into all the employees the core principles behind the company (and what makes it successful), so they probably churn out a lot of creative types who look at things the way Jobs does (i.e. that Google logo's 'o' is the wrong shade of yellow!). Obviously it's hard to replace someone with the same vision, but he's had plenty of time to write down and pass on all his ideas for the future, avenues he'd like to explore and obviously he's still on the board. Should be fine with or without him.
Look forward to reading his authorised biography.