On. Your HD won't really wear out any faster because you access it a bit more.
OFF, If you turn the computer off after use.
vista OFF
win7 ON
OFF, If you turn the computer off after use. Can take ages to preload stuff. the more memory to fill the more hd thrashing occurs which slows down execution of other apps.
ON, always.
Seriously, what's the point of leaving it off? Give one good reason - and no, HDD thrashing is NOT one as it's more likely to be Defender/Indexing.
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