It's all relative but I think if you're looking at average house prices versus average salaries for the area then it is much harder in the south/south east. I think some towns like Oxford or Cambridge are well over 13x on those sort of scales, whereas London as a whole in more like 10-11x. That's just off the top of my head, and also pre-2020 so I'd imagine those commuter towns are even worse now what with everyone moving out of London (apparently)!
I see it as a bonus in some ways.... I'm in the SE and house prices are crazy. This means that in 20/30 years time when we retire we'll have the ability to easily move to anywhere in the UK (or probably abroad if we so wished) as we'll already own property in the most expensive part of the country. It's a harder slog whilst working but puts us in a much better position in the future.
If you live in Scunthorpe I'm sure you can buy a 3 bed detached house for £130k and live very happily, but you'll never be able to move out of the area without having to worry about finances or get some crazy pay rise.
In 20 years time I can leave Surrey for anywhere in the UK and know it'll be cheaper and we'll be fine.