I realise this is a massive necro but thought it better than starting a new thread.
I recently moved everything over to WSE 2016. And I've been having a few teething issues. It's nothing ground breaking, but its certainly enough to make me consider just going to full blown Server Datacentre (as I have the licences) though it really shouldn't come to that.
Firstly well - its a little slow. I can't work out why, it's on good spec hardware, but it just is (I'm not expecting that Server 2016 would run better here, its just one of those things).
The biggest issue I'm having though is with its reliability. I'm running Drivepool on it which by all accounts has no problems with the platform, but I just lose access to the shares sometimes and have to reboot.