Basically Yes.
If they're active, feed them with multi channel line out (not sure if this is that common or not - my amp has 6 channel post-volume line out)
If they're passive, connect them normally.
You may have connector and impedance mis-matching, - the impedance will probably be on the back of each speaker and on the back of the amp. It's best if they match, but not the end of the world if they don't. (you just won't get as much power)