Depends what software you are running and what its needs are.
I wouldnt need 12GB in the first place, so hypothetically, if someone gave me a 12GB X56 tomorrow, I would set the swapfile to 2GB (mainly because I dont know enough to know if setting it to 0 would be a bad idea or not).
Edit: Beaten to it.
Let Windows handle it. You won't notice any difference with that amount of RAM.
I assume if you turn the page file off it'll force the OS to use all of the available memory?
Let Windows handle it. You won't notice any difference with that amount of RAM.