That would depend on use.
I have 2 Green as secondary drives. Mainly storage/low level general use + Steam folder (when I get a bigger SSD I'll move it).
When I do and video processing/conversion the source and destination are always on different drives so they are mainly doing large sequential reads/writes.
I never have my drive power down, since in my opinion powering up is one of the most stressful operations a HDD does, so limiting the amount of times it does this might extend it's lifespan. I suspect people using them with NAS where they will probably be starting and stopping a lot could be an issue over time for these cheap drives.
Most of the failed drives I see have seen have a start/stop count around the level of 1-2 per hours use.
For example my system is on 24/7, drives are cooled via a low speed 120mm pull fan.
WD15EADS 1500GB - Power on time 23,734 (hours), Start/Stop Count 226, Power Cycle Count 173.
WD20EARS 2000GB - Power on time 11,748 (hours), Start/Stop Count 81, Power Cycle Count 79.
Solid State drive.
OCZ-VERTEX2 - Power on time 18,502 (hours), Power Cycle Count 142.
So the oldest has been running pretty much 24/7 for over 2.7 years. Only stopped for upgrades/maintenance and power cut/windows update.
I personnally wouldn't use greens for OS drives. Red seem to be slight better, but I still wouldn't use as OS as it's seek time is a bit slow.
Blues would be ok for a general user as OS drive, but 24/7 use I'd use a black or better. Before I got my SSD I used a black and I use a RE4 at work.