Wouldn't it be simpler (and safer) to use an AIO instead? You'll have no issues with RAM clearance, you'll need fewer fans (if you set up the AIO fans to exhaust) and it'll look tidier too.
Well this just opens up the whole air cooling vs AIO debate. Is it safer to have leaky AIO's in your system? if a pump fails will it still work? There are pros and cons to both arguments.