Not really, I've had a couple of 20"x30" posters printed from 4Mp (2300x1800px or so) and they're great. The thing to remember is that as the print size goes up so does the viewing distance usually so while 300dpi is a good rule of thumb it's not rigid.AcidHell2 said:Wow. You really do need really high res pictures to print at a decent size at high quality.
Joe T said:300 dpi is what magazines use, and is deemed to be very high quality. If you drop to 180 dpi and unless you are looking at the prints from a few inches you shouldnt notice the difference. You could even go down to 120 dpi I think and not have too many problems. It really depends on viewing distance.