Quite intensely excited about Bioshock: Infinite. I really have a feeling in my bones it's going to be a landmark gaming moment for this generation of games.
Will also almost certainly try Metro: Last Night, and GTA5 (when it's finally released on the PC, so maybe not next year?). I'd say Rome 2 as well, but I still have Shogun 2 and its expansions to play so I doubt I'll get to that one for quite some time.
Definitely Bioshock: Infinite, though...