My keyboard has two main positions as depicted in the below diagram.
As I am a freak (read: left handed), I use the mouse with my left hand. When gaming I still use WASD though (cba setting up and learning new buttons for each game) so keyboard has to shift and rotate.
It can be a bit awkward if someone messages me in-game.
P.S: I should note that the 15" is currently not connected to anything and is used as a post-it note repository.
These post-it notes contain invaluable information such as how much XP each wave on DoWII The Last Stand mode gives you, which Runewords for DiabloII I am after and also the ship tier list for X3TC.