I know a few people who've absolutely no tolerance of any these programs and will swiftly avoid any game upon hearing that it's tied to Steam/Origin/other. The only digital distributors they'll deal with are Gamersgate, GOG etc.
I understand those sentiments or principles perfectly, but simply disagree as the pros outweigh the cons to me also. I use Steam almost exclusively, with Blizzard games (StarCraft 2 and in future Diablo 3), and to a lesser extent ME2 DLC, being my only exceptions..