Which ram?

Do you have any information about the System you intend to use this in?

However at a guess the 5400 will be ok for most non overclocked systems.
 
With your system even if you were clocking the PC2-5400 would do.

But as Cob said the extra fiver is worth it for the PC2-6400 as there would be greater FSB head room especially if you decide to overclock.
Plus if you decide to upgrade to Penryn/Yorkfield the higher FSB yould be an advantage.
 
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