A big part of the problem with workstations is that software companies validate their software on a limited number of platforms with quite specific hardware. Deviate from their specific hardware and software requirements and you invalidate your support contract and they won't support you when things go wrong. For example, we use Avid media composer which is validated on intel xeon's with mainly nvidia quadro cards and the odd AMD radeon pro WX card. There are zero amd cpu options. Heck they are that prescriptive, you have to have add in cards in specific motherboard slots, specific bios and driver versions, even specific bios options.
This is the same story across many software vendors when dealing with commercial support contracts.