There are clearly going to be differences in every car.
My Focus had a notable power drop with the AC on. Very noticeable.
The S2000 has code in the ECU to apply an idle throttle increase with the AC on to compensate for the extra load.
I only use AC when I feel I need it, I never leave it on. If it does not affect economy it certainly affects total power available at my right foot![]()
My Focus suffered greatly with AC both in terms of power and fuel usage.