Some tips I've learned since starting this game a couple of days ago.
Build LOADS of houses 1 square by 2 squares (1x2) vertically from a street/road. This will create a larger turnout of residents.
Build a avenue 6 squares away from the houses and build 1x3 vertically low density commercial.
Always make sure your house demand is being met. And don't build anything bigger then 1x1/1x2 of low density houses to start with.
Zone separate your industrial medium density, power and waste disposal. Set waste disposal to 0% funding, so it still collects rubbish but costs nothing. Zone separating is really easy. Choose your residential square on the region map, then right next to it choose a square for your industrial, then connect it with a avenue and you'll have an up and running industrial estate. DO NOT forget to connect your power lines through the 2 zones, otherwise your residents wont have power.
Don't rush to use mass transit, be it train, boat, bus and so on. Wait until its REALLY needed then start looking into it. Buses will increase congestion times, which makes sims unhappy and makes them abandon houses. Try to keep congestion below 60mins. Its hard but doable.
2 photos of my current attempt.
This is an example of splitting industrial medium density from your housing residents.
And these last 2 are the current example of my layout, which as you can see seems to be keeping everyone happy. Congestion is around 40mins, everyone has a job and they have no civic services yet.