Note the following from the Netgear website.
Recently, Western Digital has started releasing hard disks utilizing 4K sectors, and other disk manufacturers will be doing the same in the near future. The ReadyNAS will work with these 4K sector drives, however, we will not put these drives in the compatibility list due to the fact that partitions on the ReadyNAS are not 4K sector aligned, and thus write performance can suffer because of that. Rest assure that we are in the process of adding proper support for the 4K sector drives and will release firmware updates for all of our ReadyNAS systems to address this. However, because changes like this requires proper level of testing, we will take as long as necessary to ensure your data is not compromised.
In the meantime, please note that WD has released the 4K sector drives under the same base models as the 512-byte sector drives. For instance, the WD20EADS drive are available in both 512-byte and 4K sectors. You will need to look carefully at the notes in the compatibility list where we specifically state the full model number, include the suffix after the dash “-”. In the case of WD20EADS, we will put in the notes that the model that passed qual is WD20EADS-00R6B0. This is the 512-byte model. Whenever a suffix note is mentioned, refrain from using drives with a different suffix. We advise that if you cannot verify the suffix from the disk retailer, either avoid purchasing the drive(s) from there or ensure that the retailer has a quick return or exchange policy.
UPDATE (July 7, 2010): x86-based ReadyNAS now fully supports 4K sector drives with RAIDiator firmware 4.2.12+. See RAIDiator 4.2.12 Release Notes.
Added support for 4K sector drives. If you have already installed 4K sector drives with 4.2.11 or earlier, you can replace each disk one by one, allowing it to complete resync, and all your disks will be 4K aligned, and your performance should be on par with similar 512-byte sector drives.