It's a fantastic game, and you get so much content for your buck. There are a load of improvements over Fallout 3 such as a tweaked conversation system that makes persuasion less of a guessing game, weapon mods, richer characters (IMO), better faction system, gambling, more humour, and loads more.
Also there are some great mods out for it if you go for the PC version (the best version).
There are a few glitches, but it seems a lot of them have been patched, and I've had no trouble playing for over 60 hours.
You will, however, get sick of the radio. If I hear "Johnnie Guitar" one more time I will shove that Guitar up his Enclave! "Big Iron on his Hip" is still cool no matter how many times you hear it though.